From the North:

Take I-75 S to the US-129 S exit - exit number 451 - toward Live Oak

Turn LEFT onto US-129/FL-51/FL-57. Continue to follow FL-51 S

FL-51 S becomes 11TH ST SW/CR-136

From the West:

Take I-10 E to US-90 E/FL-10 E via exit number 275 toward LIVE OAK

Turn RIGHT onto US-129/FL-249/FL-51. Continue to follow FL-51

FL-51 becomes 11TH ST SW/CR-136